22) Evo Devo Rap song (by Theodor Zbinden)

Here is a "you tube rap song" dedicated to evo devo biology. The song was made through the Kickstarter platform that supports projects in art and teaching. The creator of the video is Tom McFadden who does all sorts of educational videos and publishes them from the Kickstarter platform. Listen first the video than read the lyrigs.

   
Regulatin' genes 

 The Lyrics:

In the dorsal or ventral, makin' proteins. Top-down, secretin' out, regulatin genes.


Here we go in the embrio-asymmetry. From the egg sac, holla back, regulatin' genes.


Jigga I don't like it if aint zinc finger or homeodomain, yo, regulatin' genes.


How you tell a cell it should be in the spleen? Or your lung? or your tongue? Yo, you regulate it's genes.


Wanna talk about development? Of a single cell into a gentleman?


Then pay attention to your head when it knocks, because it grew there thanks to HOX.


So many controls on when a gene is active. But I'm a just focus on transcription factors.


When the ventral signals inhibits cactus, that's what the SOG I call a chain reaction.


Each cell's got an identical genome, but we know the phenomenon of devo...


Depends on whether them genes is expressed. Don't be getting depressed, though it's getting complex.


Next thing is how a cell's picking which GATs (stretches of nucleotides) get chosen, like Yogi in a pic-in-ic basket.


Proteins and DNA? Some interesting chemistry cuz they gettin jiggy with some different affinities.


And if they bind then we're looking at the next phase: Block or recruit the RNA polymerase?


Whether on or off either occasion, regulated gene leads to differentiation.


In the ant or posterior, switching on things. Evo Devo, regulatin' genes.


On that non-coding region up or downstream, is a sight where you might get to regulate a gene.


Jigga head-to-tail patterning is a common theme, from a fly to a guy, check it, regulatin' genes.


Aint an issue in the tissue when we makin' blood veins. In the HOX fam, hot damn, regulatin' genes.


Hey yo, talking bout development? Of a single cell into a gentleman?


Pay attention to your spine when it pops, cuz it grew there thanks to HOX.


Contemplating Evo Devo when I got to thinkin' how many years of evolution been tinkerin?


Like 1,000,000,000. No one quite knows when HOX genes rolled up.


Showed up with their ability to regulate-segmentation whether in a mouse or in invertebrate.


I heard'em say the gap genes is turning on the pair rule (genes)...


Regulatin' H-O-X?


Got ot be careful!


The truth is for mutant Hox, my homie got it.Gotta be careful with the genes that homeotic


Mutate them on or off then you in trouble. You get some strange phenotypes including…Double (Bi) thorax, but the most whack is the gross fact…


You can grow a leg where antennae shoulda grown at!

Unbelievable? Aint no embellishment. Regulatin' genes is crucial to development.

Reference:



1. Citing webpage. The evo devo rap song. Retrieved April 8, 2013 from  http://www.youtube.com/watch?v=9k_oKK4Teco